AAN 2014

Comparison Of Classical Risk Factors, Lypids, Stress And Depression Among Patients With First Ischemic Stroke And Acute Myocardial Infarction In A Center From Buenos Aires

Dario Lisei, Martin Lopez Vicchi, Gabriel Persi, Matías Failo, Ricardo Iglesias, Maria Ballarino, Sebastian Camerlingo, Virginia Laura Parisi and Emilia Gatto

Introduction: Hypertension (HTA), dyslipemia, smoking, high BMI, diabetes, are shared risk factors (RF) for ischemic stroke (IS) and acute myocardial infarction (AMI). Stress and depression are recognized RF for vascular disease. The role of apolipoprotein-B100 (ApoB) and apolipoprotein-A1 (ApoA) in stroke as a RF is not concluding.Objetive: to analyze the distribution of classical RF, lipid profile, Apo-lipoproteins, stress and depression in patients with first IS and AMI.Design/Methods: From March/2012 to June/2013, we searched cardiovascular RF, BMI, total cholesterol (TC), low density lipids (LDL), high density lipids (HDL), triglycerides (TG), ApoB, ApoA, atherogenic index, depression, and stress in patients diagnosed with first IS and AMI within the first 5 days.Results: Eighty nine patients were evaluated, 35 AMI and 54 IS. IS patients were slightly older than AMI patients (70.7 vs. 63y.o, p: 0.0057). Smoking was frequent in AMI patients, HTA was more prevalent in IS, but without statistical significance. We did not find differences in prevalence of TC, LDL, HDL, TG, homocystein, BMI and stress between IS and AMI. Mild depressive symptoms were significantly more frequent in men with AMI. We found higher levels of ApoB in IS with respect to AMI (76.61 vs. 62.85mg%, p: 0.0029). ApoA levels were significantly lower in AMI (123.44 and 98.25mg%; p:0.0002). ApoB/ApoA ratio and atherogenic index were not significantly different between AMI and IS.Conclusions: Smoking and dyslipemia were more frequent in AMI. IS patients were older. ApoB and ApoA levels were lower in AMI. Mild depressive symptoms were significantly more frequent in men with AMI.

1. Neurology April 8, 2014 vol. 82 no. 10 Supplement P6.277