AAN 2013
Virginia Parisi; Carlos M Melcon, Leonardo Bartoloni, Tomoko Arakaki, Nelida Garreto, Jose Bueri, Hernan Pavon, Emilia Gatto
Background: Mate is a very common beverage in some countries of South America. Yerba Mate (YM) comes from the dried leaves of the small tree (Ilex paraguaiensis). This drink is called “Mate” and has xanthynes between its components. Experimental studies suggests that YM could have a neuro protective rol in development and progression of Parkinson disease (PD) probably related to the adenosine A2A receptor antagonism or an augmentation of the expression in the striatum of adenosine A1 receptor mediated by xanthynes. Our objective was to study the association between the risk of developing PD and YM consumption and quantifying its magnitude.
Material and Methods: Case-control study on an individual basis from hospital records. Case was defined as a 40 years or older PD individual with ≥ 4 years of disease duration. Other causes of Parkinsonism were excluded. Samples were matched by sex and age (± 2 years). Exposure was measure by YM consumption, coffee, tea, alcohol intake and smoking. Clinical and demographic data were recorded.
Results: This preliminary analysis included 58 cases and 171 controls. Mean age of PD diagnosis 68.4 years, mean disease duration 7.16±4.81 years. There was an inverse association between YM consumption and PD (p=0.05). Multivariate analysis with logistic regression adjusted by sex, alcohol intake and smoking showed for YM OR: 0.75(IC95%:0.57-1.00), Tea OR: 0.54, (IC95%:0.30-0.97), Coffee OR: 0.55, (IC95%:0.28-1.07). All infusions considered together had OR: 0.69, (IC95%:0.53-0.89).
Conclusions: We found an inverse association between intake of YM and PD, and a potential inverse association is suggested between YM and risk of PD. These results leads us to hypothesize that YM may have a potential protecting role in developing PD. Further studies in this direction should be conducted.
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